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Respiratory Medicine

2 10 The unsaturated acyl chains in membrane phospholipids and cholesterol in membranes, among biomolecules, are highly susceptible to pathologic free radical damage for the following reasons 16 : First, the inherent structure of polyunsaturated fatty acid chains (polyunsaturated acyl chains are normally unconjugated, and the alpha-methylenic carbons between carbons with double bonds have allylic hydrogen that can readily enter into free radical reaction